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10.15252/embj.201695810 20 CampbellJ

This study demonstrates the uptake and distribution of ET and provides a foundation for future studies with ET to target oxidative damage in a range of tissues in human diseases

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This dysregulated cholesterol metabolism affects immune cell function, inducing mitochondrial dysfunction in CD8 + T cells and MDSCs ( BOS complex subunit transmembrane protein 147 (TMEM147) is upregulated in hepatocellular carcinoma (HCC) cells

452,455 Inhibition of the ETC leads to aspartate depletion, triggering ATF4 upregulation and increasing the transcription of genes related to amino acid transport and synthesis