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pneumoniae infection is higher than 40%50% and these infections represent a major challenge in the field of infectious disease treatment ( K

10.1016/j.neuropharm.2020.108352 Neuropharmacology 194 MatsunagaS.KishiT.NomuraI.SakumaK.OkuyaM.IkutaT.et al (2018)

doi: 10.1080/14728222.2022.2170779 44 YuanZLiYZhangSWangXDouHYuXet al

Some studies have proposed the concept of mitochondrial lactate oxidation complex (mLOC), comprising mitochondrial LDH (mLDH), MCT1, and CD147, which may mediate the direct entry of lactate into mitochondria for subsequent utilization

Neutrophils contribute to RA in various ways: (I) they possess a pool of highly toxic proteases that are released at sites of inflammation (II) activated neutrophils can secrete a variety of pro-inflammatory cytokines and chemokines, causing subsequent inflammation (III) activated neutrophils form neutrophil extracellular traps, which contain externalized citrulline proteins as a source of modified autoantigens for the production of ACPAs [7]