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in: PubMed | Google Scholar 1 Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

PNPLA2 is upregulated in breast cancer cells co-cultured with adipocytes, enhancing intracellular lipolytic activity of cancer cells (210, 211)

Schimchowitsch S, Stoeckel ME, Schmitt G, Porte A

However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug

This reaction occurs in a significant percentage of patients beginning dual GLP-1 and GIP receptor agonist therapy, and understanding its cause helps you determine whether it represents a normal response or a sign requiring clinical attention