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Interestingly, NMD efficiency remains reduced even when the downstream AUG lies in a different reading frame, suggesting the existence of additional, uncharacterized mechanisms underlying NMD evasion

This precision approach eliminates the temptation to stack medicationsyour personalized single agent is more effective

This contributes to a failure in healing, as the urothelium is unable to regenerate efficiently due to the dominance of inflammatory signals

On the average, our patients seem to get the best benefits in the first 6 9 months of treatment

Ethics declarations Ethics approval and consent to participate The study was approved by the Hospital 12 de Octubre Ethical Committee (21/580), and all patients and donors provided written informed consent following the Declaration of Helsinki