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Another important aspect of astrocytic metabolism, namely glutamine uptake and conversion, was studied in the context of frontotemporal dementia

Moreover, as the mechanistic link is primarily inferred through pharmacological blockade, additional studies using direct molecular markers like p-Akt/t-Akt are needed to substantiate the role of FGF1/PI3K/Akt signaling in Tozasertibs action

Harischandra DS, Jin H, Anantharam V et al (2015) -Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinsons disease

Labont B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YHE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ (2017) Sex-specific transcriptional signatures in human depression

The JAMA Psychiatry Study One of the most prominent studies published in the journal JAMA Psychiatry (the JAMA Study) reported that biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood [autism] in a dose-response fashion. Further, the study reported that the association between exposure to acetaminophen in utero was consistent across multiple subgroups