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GHK-Cu, a variant of the peptide found in high concentrations in the brain, has been studied for its ability to counteract age-associated decline in neuron function

These compounds then undergo oxidative decarboxylation by a multiunit enzyme similar to the pyruvate dehydrogenase complex with similar cofactor requirements (section 4.1), and the remaining carbons can enter the TCA cycle

Scribner JA, Hicks SW, Sinkevicius KW, Yoder NC, Diedrich G, Brown JG, et al

As a result, one metabolic reaction was kept for one metabolite pair in each reaction class

(2023) claim that Bmal1 deletion affects several genes related to the endolysosomal system