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Clin Cancer Res 27(6):1720-1733, 2021

Eckel-MahanKPatelVDe MateoSOrozco-SolisRCegliaNSaharSet alReprogramming of the circadian clock by nutritional challenge

29,30 The senescence programme activated in different cell types due to either replicative exhaustion (telomere shorteninginduced senescence) or stress (DNA damageinduced senescence, mitochondrial dysfunctioninduced senescence, and perturbed proteostasis)

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162 A systematic literature review concluded that vigorous aerobic exercise and resistance training can lower male hormone levels and improve insulin sensitivity, while a randomized controlled trial in 61 women with PCOS found that a program of yoga exercise also may be of benefit as it reduced unwanted hair growth, abdominal circumference, and hip circumference compared with controls