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2023;61(1):doi:10.1128/jcm.01110-22 45

50% of the bodys storage of vitamin B12 is kept within the liver, no matter how it is administered, so if the liver is sick, in all likelihood, a person can suffer B12 deficiency

These results suggest improvement in insulin sensitivity, and moreover, no additional side effects to those found with placebo were observed in T1D, meanwhile in T2D patients oedema, jaw pain and arthralgias were 4 % lower than previous reports [276, 277]

Vitamin B12 is reduced to cobalamin regardless of form (cyan-, methyl-, adenosyl-, hydroxo-) then re-assembled as methylcoblamin by MS for use in the cytosol, or adenosylcobalamin by MM for use in the mitochondria