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The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)

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De Winter JR, Janssen P, Sleddens H, Verleun-Mooijman M, Trapman J, Brinkmann AO, Santerse AB, Schrder F, van der Kwast TH

This may help improve skin elasticity, hydration, and overall skin quality, which can become more noticeable as estrogen levels decline during midlife