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Iran J Basic Med Sci 18:544 El-Najjar N, Chatila M, Moukadem H et al (2010) Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

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Thus, we investigated the effects of MTHFD2 depletion on the lipid rafts content, and found a significant accumulation of lipid rafts which was further enhanced by treatment with MTX ( Figure 7A )

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HIF-1 activates DNA repair mechanisms, anti-apoptotic pathways and drug efflux pumps, enabling cancer cells to evade cisplatin-induced cell death and reducing treatment efficacy [302]