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Experimental data demonstrates upregulation of 3-adrenergic receptor expression and restoration of lipolytic responsiveness in systems where this pathway is suppressed

Given that the most common age of onset for IBD is in the second and third decades of life, patients often experience IBD for the majority of their life

[26] A complication of severe chronic PA is subacute combined degeneration of spinal cord, which leads to distal sensory loss (posterior column), absent ankle reflex, increased knee reflex response, and extensor plantar reflex response

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Regular monitoring helps ensure the frequency remains appropriate Once levels stabilise, injections are usually spaced further apart, often every few months