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doi: 10.1038/s41419-023-05778-0 57 WangR.ShiD.PanX.RenA.JiangK

FIGURE 6 10.1 Multiple proteins interact with cardiolipin to induce pore formation While several amyloidogenic proteins have been known to disrupt the plasma membrane through pore formation, recently there has been growing interest in the concept that pore formation in the mitochondrial membrane may be the primary factor that initiates neurodegenerative disease, as well as type II diabetes

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Despite these encouraging findings, most supporting evidence to date arises from in vitro experiments and animal models

The reviewer JX declared a shared parent affiliation, with no collaboration, with some of the authors, QL, HZ, WW, KL, CH, to the handling editor at the time of the review