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This contractile event leads to opening of tight junction structures, as transmembrane tight junction proteins are linked to the PAMR through peripheral membrane proteins such as ZO-1 (45)

The ligand in this case is chosen to have a sequence, structure, or restriction site that can be used to capture a protein that will interact specifically with this DNA segment [223,232]

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Although thiamine has been used to treat TD disorders due to its low bioavailability, several lipophilic thiamine derivatives have been developed