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Learn about supplement interactions with apixaban (Eliquis), rivaroxaban (Xarelto) and other blood thinner drugs in the direct factor Xa inhibitors class

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doi: 10.7759/cureus.44081

doi: 10.2147/DMSO.S391888 169

When histidine is replaced with tyrosine as in HbM, the heme moiety more readily auto-oxidizes creating the ferric (Fe 3+ ) state [12], which predisposes to methemoglobinemia in the presence of oxidizing substances [8]