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By reshaping key signaling axes (e.g., PI3K/AKT and Wnt/-catenin) and rewiring metabolic and microRNA networks, it imposes broad restraint on tumor progression

however, the sensitivity of this screening test is low, and the condition is often undiagnosed

The importance of nonaxonal pressure targets was accentuated in a landmark study by Morgans group, which demonstrated that pressure-induced dendritic retraction and RGC loss occur in the presence of intact axons (62)

UCP2 inhibition in ALS motor neurons alters bioenergetics but does not impact the redox status Previous investigations linked the uncoupling protein 2 (UCP2) to mitochondrial dysfunction in ALS 3,31,32 , so we tested the role of this protein in the bioenergetic alterations of ALS mice motor neurons observed in our study