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Exogenous melatonin supplementation can suppress the pineal gland's own output over time

Multiple studies indicated that pinealectomy or circadian disruption can stimulate spontaneous growth and development of tumors, and metastasis of the existing tumors [17, 18]

Collectively, these findings clearly indicated that FGF18 promotes hepatic fibrogenesis, anticipating a novel therapeutic target for prevention and treatment of liver fibrosis

Cytotoxic chemotherapy is the primary treatment option for TNBC (5)

Researchers consistently frame these as dose- and duration-dependent considerations requiring careful study design and monitoring