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Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

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Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) acts as the first rate-limiting enzyme to produce nucleic acid precursors by converting ribose 5-phosphate (R5P) into phosphoribosyl pyrophosphate (PRPP) 5,6 (Fig

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Ladakis DC, Harrison KL, Smith MD, Solem K, Gadani S, Jank L, et al