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Similar acute haemolytic attacks have been observed, predominantly in men of Afro-Caribbean origin, in response to primaquine and a variety of other drugs, including dapsone, the antipyretic acetylphenylhydrazine, the antibacterial bactrim/septrim, sulphonamides and sulphones, whose only common feature is that they all undergo cyclic non-enzymic reactions in the presence of oxygen to produce hydrogen peroxide and a variety of oxygen radicals that can cause oxidative damage to membrane lipids, leading to haemolysis

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Among them, HLA alleles, especially the HLA-DR1 and HLA-DR4 loci, play an important role in the development of RA by mechanisms that may be related to the formation of citrullinated antigens and immune tolerance of CD4 + T cells (Wysocki et al., 2020

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FEBS J 288(22):64926509 Editor information Editors and Affiliations Rights and permissions Copyright information 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature About this protocol Cite this protocol Gnanasekaran, P., Pappu, H.R