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Any condition that destabilizes this bond could indirectly shorten the effective GHK-Cu half life by making the peptide more susceptible to degradation

Kim SA, Jang JH, Kim W, Lee PR, Kim YH, Vang H, Lee K, Oh SB (2022) Mitochondrial reactive oxygen species elicit acute and chronic itch via transient receptor potential canonical 3 activation in mice

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Indeed, H 3 receptors are found to be upregulated in Hdc KO mice, and chemogenetic activation of these receptors in the dorsal striatum can precipitate stereotypies (Rapanelli et al., 2017) suggesting that histamine, and specifically the H 3 receptor in the dorsal striatum, are contributing to the repetitive movements that are a prominent feature of TS

8 C, D) and evoked APs firing measurements (Fig