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Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial

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5D) in human neutrophils

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Proper dosage titration involves starting at 200-250mcg daily for 2-4 weeks to establish baseline tolerance, then increasing by 50-100mcg increments every 2-4 weeks based on subjective response and side effect profile until reaching optimal therapeutic dose or maximum tolerated dose