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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

Nicotinamide (vitamin B3 (PP)) stimulates the production of nicotinamide adenine dinucleotide phosphate (NADP) and nicotinamide adenine dinucleotide (NAD), which regulate the course of most redox reactions, including the normalization of many types of energy metabolism

Walsh and Brophy, 2011