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These include widespread inflammation which impacts sensory nerve pain, metabolic changes, leaky blood and lymphatic vessels, tissue hypoxia, presence of VEGF (which stimulates new, but abnormal blood vessel growth), and abnormal quantity and size of fat cells

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With todays knowledge we can say that nitrates have a wide range of positive effects on the human body, such as: lowering blood pressure, increasing flow-mediated dilation, reducing plateletmonocyte aggregates and improvement in vascular function [7]

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These have included once again size [315, 316] and also crystalline nature [317], adsorptive ability of alveolar and serum components as well benzo(a) pyrene [318,319,320,321], and dissolution and biodegradation of mineral fibres [322, 323]