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Description

(2014) 133:49e56e

The interaction between interleukin-22 and interleukin-17 inhibits keratinocyte differentiation while increasing their proliferation and motility, leading to nuclear retention within the stratum corneum, epidermal hyperplasia (acanthosis), and elongation of the epidermal rete ridges (papillomatosis) all of which are characterized by psoriatic skin plaques (Becher and Pantelyushin 2012)

Transient receptor potential (TRP) vanilloid 4 (TRPV4) is a member of the Ca 2+ -permeable TRP superfamily

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At experimentally suitable concentrations (up to 100 M), we observed the appearance of Chc bound to three peptides and, although in much lower amounts, a fourth binding event was also detected (Supplementary Fig