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Stephanie Widmer says the science behind many of these substances is limited

Nature 464 , 121125 (2010)

In other words, your current B12 deficiency symptoms actually reflect your B12 levels from 3 months ago

(2006) A single-center, double-blinded, randomized controlled study to evaluate the relative efficacy of sublingual and oral vitamin B-complex administration in reducing total serum homocysteine levels