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Increased superoxide production was observed in all layers of the vascular wall, namely the endothelium, media and adventitia, 14 and may also increase vasoconstrictor tone via stimulation of the expression of endothelin-1 in the smooth muscle and endothelial cell layer

Front Med 7:108 Olson LG, Ambrogetti A, Sutherland DC (2003) A pilot randomized controlled trial of dexamphetamine in patients with chronic fatigue syndrome