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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Xiao L., Wang J., Zheng J., Li X., Zhao F

Major obstacles include the lack of standardized quality control for botanical extracts, poor bioavailability, unclear pharmacokinetic profiles of bioactive compounds, and insufficient high-quality evidence from randomized controlled trials to confirm efficacy and safety

TOX also increases IL-10.[ref][ref] IL-10 (interleukin 10): IL-10 is a regulatory cytokine that puts the brakes on the immune response, preventing excess tissue damage during inflammation

Every protocol is preceded by physician consultation, baseline labs, and clinical assessment of fit

The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012