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therefore, we performed co-IP and found that ACTL6A HR mutant did not bind to NRF2 (Fig

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These include sudden onset of severe leg pain, particularly if unilateral and associated with swelling or warmth (which could suggest deep vein thrombosis), progressive weakness or numbness in the legs, loss of bladder or bowel control, or symptoms accompanied by fever or signs of infection

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Among children, approximately 12.5% globally are affected, with prevalence rising to 2145% in low- and middle-income countries