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-Syn oligomers can also inhibit the import of proteins, including some subunits of complex I, into the mitochondria by binding to the translocase of the outer membrane (TOM20) and inhibiting its interaction with the co-receptor TOM22 (Di Maio et al., 2016)

This inhibition reduces the antioxidant capacity of cells, leading to an accumulation of ROS, causing further damage to cellular components and expediting cellular aging (Tan et al., 2020)

We use geostatistical simulations of baseline data from the PvSTATEM trial to explore if and how modified randomisation approaches might mitigate these impacts

Int J Fertility Steril 9:541 [DOI] [PMC free article] [PubMed] [Google Scholar] Sherif IO, Al-Shaalan NH (2022) Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis

BRCA1 and BRCA2 mutations and treatment strategies for breast cancer