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Crucially, no human trials define an optimal cycling schedule these are consensus patterns, not proven protocols, and should only be considered under a physicians supervision

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Clinical studies have shown that patients taking less bioavailable formulations of triamterene and hydrochlorothiazide in daily doses of 25 mg to 50 mg hydrochlorothiazide and 50 mg to 100 mg triamterene may be safely changed to one 37.5 mg/25 mg of triamterene and hydrochlorothiazide daily

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J Pediatr 202:315-319.e2

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