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These mitochondria are a primary source of ROS, making the kidneys especially susceptible to oxidative stress-related injury

non-Asian studies)

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[1] Although sodium bicarbonate has been employed in clinical medicine for more than a century, contemporary guidelines urge a judicious, physiology-guided approach rather than routine empirical use

Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001