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Substrates of HDACs The traditional concept supports that HDACs mainly repress gene transcription by deacetylation of histones through removing acetyl groups from their lysine residues

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First, its helpful to understand the RDA system

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Moreover, providing recombinant STAT3-activated cytokines that directly target hepatocytes, specifically IL-11 and IL-22, may be another novel pro-regenerative therapeutic option for patients with difficult-to-treat APAP-induced ALF [218]

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