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Inflammation, oxidative stress, Ca 2+ dysregulation, and hypoxia can induce cellular endoplasmic reticulum stress (ERS) by overloading the ERs protein folding mechanism ( Some studies have found that ferroptosis and ERS share a common pathway, especially in tumor diseases, and disease trends can be altered by controlling the ERS or ferroptosis pathway ( 2 Ferroptosis in RA With the study of RA disease mechanisms, it has been found that the aberrant activation of RA-FLSs, destruction of articular cartilage, overactivation of immune cells, and sustained expression of inflammatory factors are associated with ferroptosis

Hyperpigmentation happens when small areas of skin make too much melanin, forming age spots, melasma, or postinflammatory marks

doi: 10.7554/eLife.62852 168 ZhangD.ChenG.ManwaniD.MorthaA.XuC.FaithJ

Although various pathophysiological mechanisms and genetic factors have been proven to be related to NAFLD, its treatment remains challenging

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