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The Centre has conducted studies in collaboration with several companies including GSK, Pfizer, Wyeth and Mead Johnson

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found that the combination of PTT with immunogenic coreshell Au@Se NPs could enhance the positive expression of Hsp70 in cancer cells, and Au@Se NPs could effectively stimulate the maturation of DCs with antigen-presenting functions, reminding us the potential application of Se NPs in antitumor immunity ( Figure 2 Se NPs enhance natural killer cell functions Natural killer (NK) cells play a vital role in innate immune responses to cancer and infection, which is highly related to their surface receptors for recognizing tumor cells and pathogen-infected cells, leading to the activation of receptor-triggered cytotoxicity and cytokine production

Ethics statement The studies involving humans were approved by Ethics Committee of the Area Vasta Nord Ovest Toscana (Italy)