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163 Wnt/-catenin pathway in AD AD is mainly characterized by neuronal loss, the deposition of amyloid-beta plaques, and the formation of hyperphosphorylated tau protein in neurons, particularly the cytotoxic effect of amyloid beta-peptide (Abeta)

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Third, methodological differences, including the use of immortalized cell lines, animal tissues or primary organoids, to variations in barrier assays (TER versus flux of paracellular markers such as mannitol, dextran and inulin) can yield different outcomes

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