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Furthermore, in both human AD patients and animal models, MS has been considered as one of the earliest brain structures affected by neurodegeneration (Fujishiro et al., 2006

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Stec D.E., John K., Trabbic C.J., Luniwal A., Hankins M.W., Baum J., Hinds T.D

doi: 10.3389/fchem.2025.1536858 Received 29 November 2024 Accepted 27 January 2025 Published 19 March 2025 Volume 13 - 2025 Edited by Federica Aureli, National Institute of Health (ISS), Italy Reviewed by Eric Deconinck, Sciensano (Belgium), Belgium Maria Cristina Gaudiano, National Institute of Health (ISS), Italy Updates Copyright 2025 Blazewicz, Poplawska, Daniszewska, Piorunska and Karynski

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Cell mitosis is one of the most distinct histological features that differentiates the proliferative phase from the secretory phase [20, 21]