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Disruption of mitochondrial oxidative phosphorylation (using biguanides) results in complex responses that can either enhance or hinder the antitumor effects of serine and glycine starvation

First is the antioxidant paradox: chronic antioxidant supplementation can inadvertently protect circulating tumor cells (CTCs) from oxidative stress during metastasis, thereby promoting distant dissemination [203, 312, 313]

J Biol Chem 270: 1490714912

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