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In RM, a similar pattern of convergent dysfunction has been documented, with particular emphasis on the maternalfetal interface [375]

Furthermore, more than 50% of patients adjust their diet based on personal experience after diagnosis, often without professional guidance, which can lead to malnutrition and a decline in quality of life [218,219,220]

Lower mitochondrial NAD+ means lower ATP output, which shows up as fatigue, reduced physical performance, and slower recovery from exercise

However, WGBS remains the most comprehensive method for high-resolution mapping of cell type-specific methylation patterns, though its high cost limits wider use

Microbiota-derived metabolites, including SCFAs and tryptophan-derived indoles, influence baseline immune activation and neuronal excitability, effectively setting the threshold at which epithelial stress translates into inflammation