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10.1158/1078-0432.CCR-12-2334 105 HassaneinM.QianJ.HoeksemaM

4.1.1 Chemotherapy Chemotherapy has been widely used in the past decades to treat various types and stages of tumors (Ouyang et al., 2020)

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The combination of BSO+L-PAM achieved synergistic cytotoxicity (combination index number (CIN) 0.7) and induced 24 logs of cell kill in all nine MM cell lines including the eight lines established at progressive disease (PD) after therapy (U266, OPM-2, NCI H929, KMS-12-PE, EJM, TX-MM-030h, MM.1S and MOLP-2), 25 which include lines with cytogenetic profiles associated with a poor prognosis (Figure 1b)