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However, both compounds individually cause: Nausea (60-80% of users at higher doses) Vomiting (20-35%) Diarrhea (25-40%) Injection site reactions (15-25%) Potential pancreatitis (rare but serious) Combining these compounds could theoretically amplify these effects, though the actual incidence and severity remain unstudied

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In response to chemical stress, keratinocytes produce and release inflammatory cytokines, chemokines and other signaling markers that rapidly generate cutaneous inflammation 35

These risks are theoretical, not documented in human trials, but they are reasons community references include cycle off-periods

The BPC-157 and TB-500 stacking guide covers the rationale for combination protocols