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Purwanti OS, Nursalam N, Pandin MGR

EMBO J 30(4):634635 Hasan R, Lasker S, Hasan A, Zerin F, Zamila M, Parvez F, Rahman MM, Khan F, Subhan N, Alam MA (2020) Canagliflozin Ameliorates Renal Oxidative Stress and Inflammation by Stimulating AMPKAktENOS Pathway in the Isoprenaline-Induced Oxidative Stress Model. Sci Rep 10(1)

This isn't just increased flow through existing vessels

The mutant protein reduces the level of serine 473-phosphorylated AKT1 (p-AKT S473), the active form, which is critical for neuronal survival, causing diminished pro-survival signals in SCA3 models

Metabolic diseases are closely correlated with life style and changes in life style has a great deal of impact on disease patterns, about 2030 years ago, infectious disease were more than non-communicable diseases, but now the non-communicable/metabolic diseases are on the higher side