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Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT et al

Extracellular vesicles (EVs) are heterogeneous membrane-bound structures secreted by nearly all human cells

Studies have shown that Hcy-induced impairment in the transportation of L-arginine (precursor of NO) into endothelial cells and up-regulation in the generation of reactive oxygen species by NADPH oxidase results in uncoupling e-NOS

The relationship was most marked in males and females consuming more than eight cups of coffee per day

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