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46,47 These effects are mediated by SIRT1 pathway activation, which optimizes mitochondrial function and autophagy, and by miRNA-dependent regulation (e.g., miR-146a targeting Nrf2/NF-B pathways), although the mechanisms vary across cell types and microenvironments

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In other urinary system tumors, transcriptomic studies centred on macrophages have revealed an immune-regulatory mechanism driven by lipid metabolism, which also supports the existence of similar metabolic-immune mechanisms in ccRCC (Wang et al., 2023

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Deshmukh AS, Chauhan PN, Noolvi MN, Chaturvedi K, Ganguly K, Shukla SS et al (2017) Polymeric micelles: basic research to clinical practice