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Indeed, they reinforce the notion that Palbociclib and Telaglenastat are uniquely suited to counter the metabolic reprogramming induced by the reciprocal drug, thus providing a mechanistic rationale for the high effectiveness of the drug combination observed in vitro and in vivo

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Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor