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This Cysteinyl-Glycine dipeptide can either be potentially transported via PEPT2 or cleave by dipeptidase releasing cysteine and glycine ( via ASCT family members but can also be oxidized and imported via xCT

doi: 10.1186/s12984-024-01505-8, 56 LeeD

A systematic review of 35 studies found consistent age-related GSH decline in blood and specific brain regions, including the precuneus, hippocampus, cingulate, and frontal cortex

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For example, mitochondrial autophagy can maintain a healthy number of mitochondria, prevent damage caused by mitochondrial morphology destruction, reduced oxidative phosphorylation activity, mitochondrial membrane potential collapse, and ATP synthesis, enhance mitochondrial autophagy, inhibit mitochondrial metabolic processes, reduce GSH rapid consumption caused by Cys deprivation, lipid ROS generation, and ferroptosis (Gao et al., 2019