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Key Functions: Essential component of at least 25 selenoproteins in the human body Central to glutathione peroxidase function, which neutralizes peroxides Supports production of thioredoxin reductase, an enzyme involved in DNA synthesis and redox regulation Protects cell membranes from lipid peroxidation Helps recycle vitamin C, enhancing its antioxidant capacity Selenium deficiency severely compromises the body's antioxidant defenses and has been linked to increased risk of certain cancers, cardiovascular disease, and thyroid dysfunction

doi: 10.3390/ijms24054689 24 ChenSYangWGuoZLvXZouY

doi: 10.1007/s12325-019-00915-8 62 HansenBBNuhohoSAliSNDang-TanTValentineWJMalkinSJPet al

35, 109076 (2021), Abstract Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo: Shahini, A., Rajabian, N., et al

This adjustment is mainly mediated by HIF-2 (hypoxia-inducible factor 2 alpha), a key HIF isoform mostly related to long-term responses [20]