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The peptide appeared to counteract L-NAME-induced hypertension while also reversing L-arginine-induced hypotension [8]

Given what we do understand about the potential action on cellular signaling pathways this could pose serious risk

In addition, the upregulation of SIRT7 expression significantly improves renal EMT and subsequent renal fibrosis in hypertensive mice and reverses the decreased KLF15 expression induced by Ang II

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