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In contrast to pyruvate carboxylase deficiency, fasting hypoglycemia and hyperammonemia are not expected features of pyruvate dehydrogenase complex deficiency

Smoking and excessive alcohol intake contribute to stress, reducing enzyme efficiency, whereas moderation preserves balance

Activation of Nrf2 by either cellular redox status or pharmacological intervention leads to the up-regulation of over 250 genes encoding proteins that are involved in antioxidant defense systems, redox homeostasis, and xenobiotic detoxification [81]

De Vos FY, Bos AM, Schaapveld M, et al

10.1016/j.jacc.2008.08.067 33 FangX.CaiZ.WangH.HanD.ChengQ.ZhangP.et al (2020)