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Additionally, the trypanothione reductase gene is amplified in antimony-resistant isolates, leading to high intracellular trypanothione levels and increased resistance to SbIII ( Sequestration and rapid drug efflux also contribute to antimony resistance

Nat Neurosci 9:331339 Riquelme PA, Drapeau E, Doetsch F (2008) Brain micro-ecologies: neural stem cell niches in the adult mammalian brain

RT-qPCR assays confirmed a decrease in FXN gene expression in patient-derived fibroblasts (Fig

We also tried an additional approach for solubilising Trx-mGH where the volume of resuspension buffer (6 mL) was evenly divided over the three freezethaw cycles (2 mL per cycle)