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Description

The traditional classification of microglial phenotypes into binary M1 (pro-inflammatory) and M2 (anti-inflammatory/neuroprotective) categories has provided a useful conceptual framework, though it is increasingly recognized as an oversimplification of their functional diversity (Figure 5)

DAT, a member of the Na + /Cl -dependent family of neurotransmitter transporters (382) is therefore a major therapeutic target for schizophrenia and other disorders (383385)