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It has been reported that buthionine sulfoximine (BSO), a GSH synthesis inhibitor, treatment induced or worsened radiation-related disease and health risk in mice, such as cataracts 16 , brain inflammation 10 , hypertension 17 , atherosclerosis 18 , decreased HDL levels 19 , increased oxidative DNA damage 20 , and tumorigenesis 21

While they do not fully restore cartilage, they can help relieve symptoms and slow further cartilage damage

Muffly T, McCormick TC, Cook C, Wall J

The expression of astrocyte plasma membrane glutamate transporter SLC1A3 (EAAT1) decreased with aging in the mouse cerebellum and olfactory bulb (Ma et al., 2020)